Endocrine Abstracts

Central diabetes insipidus (CDI) is a common complication after transsphenoidal treatment for tumors of the sellar region and may exhibit different patterns: transient, permanent or triphasic.The aim of our study was to determine the incidence and course of the CDI and to characterize the factors associated with resolution of this disease.The incidence of CDI was based on records of 318 patients who underwent transsphenoidal surger...

BackgroundThere are no specific markers for parathyroid carcinoma (PC) therefore, the development of algorithms for identifying high-risk patients is an urgent task.AimsTo determine clinical and laboratory predictors of PC and identify the factors of a poor prognosis.Materials and methodsA multi-center retrospective study included 242 patients with primary hyperpa...

Aim: To assess the diagnostic value of a 3% hypertonic saline infusion test in comparison with a set of clinical and laboratory data (including a water deprivation test and MRI data) for the purpose of differential diagnosis between ADH deficiency and primary polydipsia (PP).Materials and Methods: An interventional comparative study included 90 patients with confirmed polyuria-polydipsia syndrome. In order to assess the diagnostic characteristics, all su...

Introduction: Vitamin D plays an important role in the regulation of the mother-placenta-fetus systemensuring normal growth, weight and development of the fetus, reducing the risks of gestational diabetes mellitus, eclampsia and preterm labor. There is insufficient data in the literature on the vitamin D metabolic pathways in pregnant women, and the available results require confirmation using more accurate methods of determination.Objective: To study of...

Introduction: Endocrinopathies are one of the most common autoimmune adverse events (AIAEs) causing severe toxic complications during the use of checkpoint inhibitor therapy (CPI).Clinical Case: A patient with complaints of hyperpigmentation of the skin of the back in August 2022 an excisional biopsy was performed and pigmented epithelioid cell melanoma with tumor growth along the resection margin was verified. In December 2022, CT revealed metastases in...

Introduction: Hypophosphatasia is a group of inherited disorders characterized by the impaired mineralization of bones and/or teeth and low serum alkaline phosphatase (ALP) activity. It is caused by a mutation in the ALPL gene encoding the isoenzyme of ALP resulting in a loss of function. Since an early age of onset is usually associated with a more severe disease, and a late age – with a mild course of the disease, the manifestation of the disorder ranges from a life-thr...

Introduction: Parathyroid carcinoma (PC) is one of the rarest endocrine malignancies. Most PCs are sporadic, sometimes occurring in the framework of familial primary hyperparathyroidism (PHPT). PHPT due to PC is usually characterized by significantly increased PTH levels, severe hypercalcemia, larger tumor size and a higher incidence of disease complications. Clinical case: A 56-year-old male C. presented with an accidental formation at the posterior con...

Introduction: According to published data, pregnancy-associated osteoporosis is a rare disease, the pathophysiology of which is currently not fully explored.Сlinical case: In 2014, a 27 year-old patient B. after the first childbirth, pain appeared in the lumbosacral spine, for which a course of physical therapy was carried out with a short-term positive effect. In 2016 after the second childbirth, pains increased; according to the results of further ...

Introduction: Transnasal adenomectomy is the main treatment for various pituitary adenomas. The hypothalamic-pituitary region is the site of synthesis and secretion of several hormones that have a direct effect on sodium-water metabolism, which leads to its frequent violation with the development of central diabetes insipidus and severe transient hyponatremia, the latter of which is the second most important cause of rehospitalization in the postoperative period. Currently, th...

Introduction: Approximately 20% of patients with prolactinomas do not respond satisfactory (resistant) even to high dose dopamine agonist treatment. Worth noticing that there are no clear prognostic signs of treatment’s resistance as well as its etiology is a subject of discussion. Aim: The aim of our study was to assessabsorption and metabolism of cabergoline in patients with dopamine agonist-resistant prolactinomas.Materials...